Nitin Jain, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the combination use of BTK inhibitors (ibrutinib and acalabrutinib) and the BCL-2 inhibitor, venetoclax, in patients with chronic lymphocytic leukemia (CLL), and clinical studies evaluating their use, including the Phase II CAPTIVATE trial (NCT02910583). This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).