Shaji Kumar, MD, Mayo Clinic, Rochester, MN, discusses the BELLINI trial (NCT02755597). The study evaluated the combination of venetoclax with bortezomib and dexamethasone (VenBd) in patients with relapsed/refractory multiple myeloma who received 1-3 prior therapies. Updated results continue to show significant improvement in progression-free survival, although the difference in overall survival is no longer significant. Dr Kumar reveals that a biomarker-based approach might be necessary for the selection of patients most likely to respond to venetoclax-based treatments. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.