Mark Drummond, MB ChB, PhD, FRCPath, Beatson West of Scotland Cancer Centre, Glasgow, UK, discusses the novel therapies for systemic mastocytosis. He explains the results thus far for the EXPLORER trial of avapritinib in patients with advanced symstemic mastocytosis (NCT02561988), and mentions the upcoming PIONEER trial (NCT03731260). This interview took place at the Myeloproliferative Neoplasms Conference 2019 in London, UK.