Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, comments on the preliminary safety and tolerability of a bicistronic CD19xCD22-directed CAR T-cell therapy in patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). Dr Kamdar highlights the promising early data, with two complete responses and one partial response observed in eight efficacy-evaluable patients, and notes that the study has shown good safety signals, with no grade 3 or higher cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS) seen to date. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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