In this video, Swaminathan Iyer, MD, University of Texas MD Anderson Cancer Center, Houston, TX, explains how categorizing subsets of T-cell lymphoma can improve clinical trial design and approaches to treatment. Dr Iyer first discusses some novel ways in which T-cell malignancies are being assessed, and further highlights novel immunohistochemistry approaches that are being used to move the field forward. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.