Christopher Hourigan, DM, DPhil, FACP, FRCP, of the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, describes a novel proteomic approach to characterize the non-cellular compartment of the bone marrow microenvironment in acute myeloid leukemia (AML) and outlines how this provides mechanistic insights into AML etiology as well as guiding efforts in future targeted therapies and immunotherapy. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).