Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, discusses the DEFIFrance study. This study collected real-world data on the safety and effectiveness of defibrotide in France in patients with veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) after hematopoietic stem cell transplantation (HSCT). The efficacy and safety observed in this study support the utility of defibrotide for treating severe/very severe VOD/SOS post-HSCT in a real-world setting. Its findings highlight the importance of prompt diagnosis and continued treatment until full resolution of symptoms is achieved. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.