Stefano Luminari, MD, (IRCCS) Reggio Emilia, Reggio Emilia, Italy, discusses the management of follicular, mantle cell, and marginal lymphoma in Italy, including local management with radiotherapy in patients with limited-stage disease, the use of immuno-chemotherapeutic agents as well as maintenance therapies in follicular lymphoma specifically. Dr Luminari also evaluates treatment approaches for relapsed lymphoma, including novel agents for relapsed/refractory disease such as lenalidomide. In the future, Dr Luminari highlights the benefit of chemotherapy-free approaches as well as CAR T-cell therapies that are being explored in clinical trials. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).