Nigel Russell, MD, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, comments on an analysis from the AML19 trial (NCT01093514) comparing CPX-351 to FLAG-Ida-based chemotherapy in patients with adverse risk cytogenetics. Whilst the study did not show an overall survival (OS) benefit for CPX-351, there was a trend towards a benefit in relapse-free survival (RFS) in patients treated with CPX-351. In addition, patients with secondary AML genomic characteristics had superior survival outcomes with CPX-351. This interview took place at the 28th Congress of the European Hematology Association (EHA) 2023 in Frankfurt, Germany.
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