ASH 2023 | Inhibiting HbS polymerization to treat SCD: insights from a Phase II trial
Santosh Saraf, MD, University of Illinois Hospital, Chicago, IL, presents preliminary findings from a Phase II trial (NCT05431088) investigating the efficacy of the next-generation sickle hemoglobin (HbS) polymerization inhibitor GBT021601 for the treatment of patients with sickle cell disease (SCD). The findings indicate good tolerability and a 3 g/dL increase in hemoglobin concentration from baseline. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Agios, Novartis, BEAM Therapeutics, Forma Therapeutics, GBT/Pfizer
Advisory board: Agios, Novartis, BEAM Therapeutics, Forma Therapeutics, GBT/Pfizer
Research Funding: Novartis, Forma Therapeutics, GBT/Pfizer
Speakers Bureau: GBT/Pfizer
