A notable feature of SARS-CoV-2 pathogenesis is COVID-19 associated coagulopathy (CAC), which is characterized by increased thrombotic and microvascular complications. George Goshua, MD, and Alfred Ian Lee, MD, PhD, Yale School of Medicine, New Haven, CT, measured markers of endothelial cell (EC) and platelet activation, PAI1 and coagulation factors in stable and critically ill patients hospitalized with COVID-19 to discern the pathophysiology of CAC. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).