ASH 2023 | Impact of TMTV on PFS following glofitamab treatment in R/R DLBCL
Joshua Brody, MD, The Tisch Cancer Institute Mount Sinai, New York, NY, discusses a follow-up from a Phase II trial (NCT03075696) investigating outcomes of glofitamab treatment in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) dependent on total metabolic tumor volume (TMTV). The findings reveal significantly worse outcomes for patients above the median TMTV, with a 12-month progression-free survival (PFS) of 15% compared to 50% in patients with a lower-than-average TMTV. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Research Funding: SeaGen, Merck, BMS, Pharmacyclics, ADC Therapeutics, Epizyme, Genentech, Inc., Kite
Consultancy: SeaGen, Merck, BMS, Pharmacyclics, ADC Therapeutics, Epizyme, Genentech, Inc., Kite
