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SOHO 2025 | Could MRD become a surrogate endpoint for drug approval in AML?
Alexander Perl, MD, University of Pennsylvania, Philadelphia, PA, comments on the potential role of measurable residual disease (MRD) as a surrogate endpoint for drug approval in acute myeloid leukemia (AML), emphasizing the need to measure MRD in patients with FLT3-ITD-positive and NPM1-mutated disease. Dr Perl highlights the importance of using sensitive MRD assays to monitor relapse-free survival and guide therapy decisions. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX.
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