Keith Wilson, MBBS, FRCP, FRCPath, Cardiff University, Cardiff and Vale University Health Board, Cardiff, Wales, briefly explains the need to improve second-line treatment options for patients with diffuse large B-cell lymphoma (DLBCL). Dr Wilson first discusses the role of transplantation as a second-line therapy, and then emphasizes the need to improve options for patients who relapse or do not respond. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.