David Sallman, MD, Moffitt Cancer Center, Tampa, FL, outlines the caveats of the Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndromes (MDS), and comments on the potential impact of the new molecular IPSS (IPSS-M) in treatment decisions. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.