iwCLL 2023 | Ibrutinib induces hypertension and cardiac arrhythmia by targeting CaV1.2 calcium channels
In this video, Juejin Wang, MD, PhD, Nanjing Medical University, Nanjing, China, presents preliminary data into the investigation of the underlying mechanisms which may cause hypertension and cardiac arrhythmia in many patients with chronic lymphocytic leukemia (CLL) who are treated with ibrutinib. Through isolating arteries of animal models, Dr Wang and his team found upregulation of the CaV1.2 calcium channel, which may therefore be a target for controlling hypertension in ibrutinib-treated patients in the future. This interview was recorded at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.
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