Dyskeratosis congenita is a multisystem disorder caused by impaired telomere maintenance. In this interview, Akshay Sharma, MBBS, of St. Jude Children’s Research Hospital, Memphis, TN, outlines the outcomes of patients with dyskeratosis congenita treated with reduced-intensity conditioning based hematopoietic cell transplantation (HCT). This interview took place during the Transplantation & Cellular Therapy (TCT) 2021 Meetings.