Sattva Neelapu, MD, Anderson Cancer Center, Houston, TX, outlines an analysis of large B-cell lymphoma patients who relapsed post-axi-cel. The loss of CD19 due to the downregulation and alternating splicing of the gene is believed to be responsible for relapse after treatment with this CAR. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.