Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses updated data from a Phase II trial (NCT02756897) of ibrutinib and venetoclax for patients with chronic lymphocytic leukemia (CLL). Results were presented with a median follow-up of 36.3 months with a focus on measurable residual disease (MRD). The study found that 50% conversion of bone marrow MRD+ to undetectable MRD was achieved from cycle 12 to 24 with ongoing combination therapy. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.