ASH 2023 | Real-world outcomes following dose reduction of first-line ibrutinib in patients with WM
Jorge Castillo, MD, Dana-Farber Cancer Institute, Boston, MA, discusses real-world outcomes of dose modifications of the first-generation BTK inhibitor (BTKi) ibrutinib in first-line treatment of patients with Waldenström’s macroglobulinemia (WM). Dr Castillo highlights that dose reductions do not impact patient outcomes, suggesting that this is a feasible method to manage toxicities while sustaining the therapeutic benefits of ibrutinib. Data on dose reduction of second-generation BTKi’s, such as acalabrutinib and zanubrutinib, is needed. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Pharmacyclics, BeiGene, Cellectar, AstraZeneca, Mustang Bio, Kite, Loxo, Abbvie
Research Funding: Pharmacyclics, BeiGene, Cellectar, AstraZeneca, Loxo, Abbvie
