ASH 2022 | Triplet combination of azacitidine, venetoclax & gilteritinib for patients with FLT3-mutated AML
Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, outlines updates results from a Phase I/II study evaluating the triplet combination of azacitidine, venetoclax and gilteritinib in patients with either relapsed/refractory (R/R) FLT3-mutated acute myeloid leukemia (AML) or newly diagnosed FLT3-mutated AML. In the R/R cohort, a high response rate was achieved, with an overall median survival of approximately six months. In the frontline setting, all patients responded to the regimen, with most patients achieving complete remission (CR). Many patients in the newly diagnosed cohort also achieved measurable residual disease (MRD) negativity. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
Stemline Therapeutics: Research Funding; Takeda Oncology: Consultancy, Research Funding; Pfizer: Consultancy; Novartis: Consultancy; AstraZeneca: Consultancy; Astellas: Research Funding; Amgen: Consultancy, Honoraria.
