Richard Silver, MD, Weill Cornell Medical College, New York, NY, discusses anticipated clinical trials for the treatment of myeloproliferative neoplasms (MPNs) upcoming in 2021. Prof. Silver suggests that future clinical trials may begin to explore the combination of different interferons for the treatment of MPNs as well as the dosing of interferons. Prof. Silver also highlights the long-term side effects experienced with the use of interferons and the importance of using low-dose interferons over a sustained period as opposed to high-dose interferons. This interview took place at the Texas MPN Workshop: Second Annual Workshop and Meeting in 2021.