Work by Patricia Mongini has recently shown a role for CpG DNA and IL-15 synergistically working to drive B-cell chronic lymphocytic leukemia cell clonal expansion. Here, Nicholas Chiorazzi, MD, of the Feinstein Institute of Medical Research, Manhasset, NY, discusses the findings of this interesting work. This interview took place at the European Research Initiative on CLL (ERIC) International Meeting 2018, held in Barcelona, Spain.