Raphael Itzykson, MD, PhD, Saint-Louis Hospital AP-HP Paris France, Paris, France, discusses the development of the niche-like ex vivo high throughput (NEXT) platform, a multiparametric drug sensitivity screening platform for primary acute myeloid leukemia (AML). The platform was validated in patients with NPM1 mutant AML treated with conventional daunorubicin plus cytarabine (DNR-AraC) chemotherapy. The results found that the NEXT assay could predict measurable residual disease (MRD) achievement in NPM1 mutant AML and identify novel sensitizers to DNA-AraC. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.
Raphael Itzykson, MD, PhD, has received research funding from Janssen, Novartis and Oncoethix (now Merck); has received honoraria from Sanofi, BMS and Celgene; and has done consultancy work with Novartis, Otsuka Pharma, Jazz Pharmaceuticals, Karyopharm and StemLine.