ASH 2023 | Mitigating CRS following glofitamab treatment in R/R DLBCL
Joshua Brody, MD, The Tisch Cancer Institute Mount Sinai, New York, NY, provides insights into the management of cytokine release syndrome (CRS) following glofitamab treatment in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Data from a Phase I/II study (NCT03075696) reveals that CRS can be mitigated by administering glofitamab in a step-up dosing regimen, or with prophylactic steroids, with dexamethasone being more effective than prednisone. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Research Funding: SeaGen, Merck, BMS, Pharmacyclics, ADC Therapeutics, Epizyme, Genentech, Inc., Kite
Consultancy: SeaGen, Merck, BMS, Pharmacyclics, ADC Therapeutics, Epizyme, Genentech, Inc., Kite
