Michael Bishop, MD, University of Chicago Medical Center, Chicago, IL, discusses the possibility of CAR-T cells in replacing autologous stem cell transplantation (ASCT) in diffuse large B-cell lymphoma (DLBCL). This interview took place at the 5th International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) 2019, held in Berlin, Germany.