A new consensus grading system for cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and cytopenias, potential side effects of CAR T-cell therapy, has been proposed. This is discussed here by Sattva Neelapu, MD, University of Texas MD Anderson Cancer Center, Houston, TX, at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.