ASH 2023 | Mechanism of action of mitapivat and its potential in the treatment of SCD
Myrthe van Dijk
• 1 Dec 2023
Myrthe van Dijk, MD, UMC Utrecht, Utrecht, The Netherlands, explains the mechanism of action of mitapivat, an allosteric activator of pyruvate kinase with potential therapeutic efficacy in sickle cell disease (SCD). Activation of pyruvate kinase enhances metabolic processes within red blood cells to prevent their deoxygenation and the polymerization of hemoglobin S (HbS) molecules. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Research Funding: Axcella Health Inc., Agios Pharmaceuticals Inc.
