Srdan Verstovsek, MD, PhD, of the University of Texas MD Anderson Cancer Center, Houston, TX, discusses the use of machine-learning to predict hydroxyurea failure and incidence of thromboembolic events with hydroxyurea and ruxolitinib switch therapy in polycythemia vera patients. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).