So clonal hematopoiesis predisposes to myeloid neoplasia, which in itself is a risk factor for venous thrombosis. But even in the absence of that, before the development of overt malignancy, JAK2-driven clonal hematopoiesis in particular, which depending on the series is either the fourth or fifth most common driver mutation in CH, has been associated with both arterial events, coronary artery disease, and acute myocardial infarctions, and with venous thromboembolism...
So clonal hematopoiesis predisposes to myeloid neoplasia, which in itself is a risk factor for venous thrombosis. But even in the absence of that, before the development of overt malignancy, JAK2-driven clonal hematopoiesis in particular, which depending on the series is either the fourth or fifth most common driver mutation in CH, has been associated with both arterial events, coronary artery disease, and acute myocardial infarctions, and with venous thromboembolism. So, you know, it’s not a huge risk factor compared to some of the others for venous thromboembolism that are well known, like the germline factor V Leiden and prothrombin 20210 and some of the other risk factors for VTE, but it does appear to be independently associated with that. That’s work most recently of Becky Zon in Boston and her colleagues.
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