Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, tells about the work being done on chronic lymphocytic leukemia (CLL) in her lab. Dr Scarfo specifically mentions a study she is working on that is characterizing CLL cells at relapse during treatment with ibrutinib. This interview took place at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands.