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ASH 2022 | Advances in pyruvate kinase activators for MDS and PKD: mitapivat & AG946

Hanny Al-Samkari, MD, Massachusetts General Hospital, Boston, MA, highlights recent developments in pyruvate kinase activators to treat pyruvate kinase deficiency (PKD) and diseases of hemolysis and ineffective erythropoiesis including myelodysplastic syndromes (MDS), commenting on mitapivat and AG946. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Disclosures

Argenx: Consultancy; Novartis: Consultancy; Moderna: Consultancy; Dova: Consultancy, Research Funding; Forma: Consultancy; Rigel: Consultancy; Amgen: Research Funding; Sobi: Consultancy, Research Funding; Agios: Consultancy, Research Funding.