In this video, Srdan Verstovsek, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, highlights some exciting novel agents and targets being investigated for the treatment of myeloproliferative neoplasms (MPNs), drawing focus on the potential of calreticulin-targeted agents. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.