ASH 2023 | The sequencing of CD19-targeting CAR-Ts and CD20-targeting bispecifics in DLBCL
Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, provides a comprehensive overview of the CD19-targeting CAR-T products and CD20-targeting bispecific T-cell engagers that are currently FDA-approved for the treatment of diffuse large B-cell lymphoma (DLBCL) and considers optimal sequencing of these immunotherapies. She mentions pivotal trials that have led to the approval of CAR-T products in this patient population (ZUMA-1; NCT02348216, TRANSCEND-NHL-001; NCT02631044, JULIET; NCT03960840), as well as the bispecifics glofitamab and epcoritamab. Emphasizing the efficacy of both bispecifics and CAR-Ts in the third-line setting, Dr Kamdar suggests a preference for CAR-Ts due to their greater curative potential. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: AbbVie, AstraZeneca, Celgene/ Bristol-Myers Squibb, Adaptive Biotechnologies, ADC therapeutics, Beigene, Genentech, syncopation, caribou biosciences
DMC: Genentech, Celgene
Research Funding: Novartis
Speakers Bureau: SeaGen
