So plamotamab is a CD3, CD20 bispecific antibody currently being studied in a Phase I study of B-cell non-Hodgkins lymphoma patients. So we presented data on the safety and efficacy of two cohorts. One was weight-based dosing strategy and the second was a cohort of patients with flat dosing after a period of step up, and the flat dosing will be moving forward as the recommended Phase II dosing. So we’re reporting safety outcomes and efficacy for those patients that have been treated thus far...
So plamotamab is a CD3, CD20 bispecific antibody currently being studied in a Phase I study of B-cell non-Hodgkins lymphoma patients. So we presented data on the safety and efficacy of two cohorts. One was weight-based dosing strategy and the second was a cohort of patients with flat dosing after a period of step up, and the flat dosing will be moving forward as the recommended Phase II dosing. So we’re reporting safety outcomes and efficacy for those patients that have been treated thus far.
What we see in the overall cohort is a low rate of high-grade CRS. And so if we take all patients in the weight based cohort, that incidence was low. In the flat based dosing, we actually didn’t see any Grade 3 or 4 CRS, it was all Grade 1 and Grade 2, and primarily in the first dose. And so that’s a very, I think, promising platform to develop as the recommended Phase II dose.