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IMS 2025 | Meet the Expert Session at IMS 2025: outpatient administration of immunotherapy for myeloma

Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, comments on the growing recognition of outpatient administration of immunotherapy for multiple myeloma, including CAR-T and bispecific T-cell engagers. Dr Lin notes that Mayo Clinic and Emory University are exploring different approaches to safely implementing outpatient management, with a focus on accounting for local regional resource capabilities and adapting to common side effects. This interview took place at the 22nd International Myeloma Society (IMS) Annual Meeting in Toronto, Canada.

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Transcript

At IMS 2025, Dr Ajay Nooka from Emory University and I myself will be doing the Meet the Expert session for setting up outpatient management for novel immunotherapy. And this is, I think, recognized by many academic centers and community practices who are getting into CAR-T and or bispecific T-cell engagers, recognizing the number of patients who could qualify for this therapy, but there are limited hospital beds...

At IMS 2025, Dr Ajay Nooka from Emory University and I myself will be doing the Meet the Expert session for setting up outpatient management for novel immunotherapy. And this is, I think, recognized by many academic centers and community practices who are getting into CAR-T and or bispecific T-cell engagers, recognizing the number of patients who could qualify for this therapy, but there are limited hospital beds. And with evolving practice and the toxicity profiles of therapies that could lend themselves very well to outpatient management. So there are definitely many flavors of how to do outpatient. I think Dr Nooka and I myself would talk about how Mayo Clinic and Emory are doing things slightly different but with the same concept, right, how to do it safely, accounting for infrastructure setup, local regional resource capabilities. So I think we’ll both share our experience and hope that that’s helpful for the people who attend the session. I think many, including ourselves, many centers are learning how to adjust and adapt the ways that we would manage for common side effects like cytokine release syndrome and neurologic toxicities. And in particular, I will speak to how Mayo Clinic is really getting into the use of artificial intelligence and machine learning to hopefully be more patient-individualized in our risk-adaptive management.

 

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Disclosures

Research Funding – Janssen, BMS; Consulting – Janssen, Sanofi, BMS, Pfizer, Regeneron, NexImmune, Caribou, Genentech; Advisory Boards – Janssen, Sanofi, BMS, Regeneron, Genentech; DSMB – Pfizer; Scientific Ad Boards – Caribou, NexImmune. All funds to institution.