Thomas Prebet, MD, PhD, Yale School of Medicine, New Haven, CT, discusses a key strategy to find novel agents to use in combination with hypomethylating agents (HMAs) in higher-risk myelodysplastic syndromes (MDS). The end goal is to improve patient outcomes while mitigating increased side effects, such as hematological toxicity, that are often intolerable in vulnerable populations. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.