AFM13 is a first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy. Here Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, discusses the trial of AFM13 plus pembrolizumab in patients with relapsed/refractory Hodgkin lymphoma after brentuximab vedotin failure (NCT02665650). This interview took place at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.