ASH 2018 | Stapled peptide ALRN-6924 for AML and MDS
The stapled peptide ALRN-6924 is the first known to simultaneously target two important p53 inhibitors; murine double minute-X (MDMX) and murine double minute-2 (MDM2), restoring the ability of p53 to induce cell cycle arrest and apoptosis in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Here, David Sallman, MD, of the Moffitt Cancer Center, Tampa, FL, tells us about the promising preliminary data from the Phase I/Ib dose escalation study, which evaluated ALRN-6924 alone and in combination with cytarabine. This interview took place at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA.
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