After the successful use of PD-L1 inhibitors in solid tumors, these agents are now being explored in diffuse large B-cell lymphoma (DLBCL). Here, Anas Younes, MD, of Memorial Sloan Kettering Cancer Center, New York City, NY, discusses the preliminary analysis of a Phase I/II study on the use of atezolizumab in combination with R-CHOP in patients with DLBCL (NCT02596971). Presented at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA.