Shuh Ying Tan, MBBS, BMedSci, FRACP, FRCPA, St Vincent’s Hospital Melbourne, Melbourne, Australia, comments on how transfusion support can be optimized for patients with myelodysplastic syndromes (MDS) and factors that should be considered, including the degree of anemia, age of the patient, and comorbidities. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.