Joel Buxbaum, MD, Scripps Research, La Jolla, CA, discusses in detail the genetic signatures associated with hereditary ATTR amyloidosis. Specifically discussed is how the pattern of penetrance of ATTR amyloidosis is dependant on a small number of genes (20-30 genes). Additionally, the genetic element relating to age-of-onset is also delineated. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).