IMS 2023 | Understanding the concept of MGRS
Nelson Leung, MD, Mayo Clinic, Rochester, MN, discusses monoclonal gammopathy of renal significance (MGRS), a classification of B-cell or plasma-cell clonal disorders that results in kidney disease. Dr Leung highlights that clone-directed therapy is necessary for preservation of kidney function in MGRS, but that prolonged therapy is generally not required to see a response. This interview took place at the 20th International Myeloma Society (IMS) Annual Meeting, held in Athens, Greece.
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Transcript (edited for clarity)
MGRS is a new classification of clonal disorders that cause kidney disease. Currently we know that this can be caused by a plasma cell clone, a B-cell clone, which mostly are LPL clones and CLL clones. The main importance of the concept of MGRS is that, in these diseases, clone-directed therapy is necessary for preservation of kidney function. However, unlike in multiple myeloma, extended prolonged therapy is generally not required...
MGRS is a new classification of clonal disorders that cause kidney disease. Currently we know that this can be caused by a plasma cell clone, a B-cell clone, which mostly are LPL clones and CLL clones. The main importance of the concept of MGRS is that, in these diseases, clone-directed therapy is necessary for preservation of kidney function. However, unlike in multiple myeloma, extended prolonged therapy is generally not required. Generally, time-limited therapy is sufficient to result in renal response and a prolonged remission.
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