Efterpi Kostareli, PhD, Queen’s University Belfast, Belfast, UK, speaks at the British Society for Haematology (BSH) 2019 Annual Meeting, held in Glasgow, UK. She discusses the enhancer landscape in chronic lymphocytic leukemia (CLL) upon BTK inhibition. Using pre and post ibrutinib treatment CLL patient samples, a longitudinal analysis of global post-translational modifications (PTMs) revealed significant heterogeneity between patients and time points.