Deborah M. Stephens, DO, of Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT, discusses treatments for young and fit patients who are at high risk and are newly diagnosed with chronic lymphocytic leukemia (CLL). The use of Bruton tyrosine kinase (BTK) inhibitors are preferentially used for this patient population whilst novel agents in combination with BTK inhibitors are currently being explored. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.