Stephan Stilgenbauer, MD, of the University of Ulm, Ulm, Germany, speaks at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA. He discusses how the genetics of chronic lymphocytic leukemia (CLL) impacts outcome in patients, with particular reference to IGHV, TP53 and MYC mutations. He talks about strategies to prevent Richter’s transformation using existing and novel treatments.