ASH 2023 | Obinutuzumab, ibrutinib, and venetoclax in high-risk CLL: the CLL2-GIVe and CLL13 trials
Stephan Stilgenbauer, MD, University of Ulm, Ulm, Germany, speaks on the Phase II CLL2-GIVe trial (NCT02758665), which found promising safety and efficacy results for the triplet combination of obinutuzumab, ibrutinib, and venetoclax in patients with previously untreated high-risk chronic lymphocytic leukemia (CLL) with del(17p) and/or TP53 mutation. Following this, the Phase III CLL13 trial (NCT02950051) showed the superiority of this triplet regimen over doublet therapy in patients with unmutated IGHV. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Amgen, Abbvie, Celgene, Gilead, GSK, Roche, Janssen, Novartis, Sunesis, AstraZeneca; Honoraria: Amgen, Abbvie, Celgene, Gilead, GSK, Roche, Janssen, Novartis, Sunesis, AstraZeneca; Travel support: Amgen, Abbvie, Celgene, Gilead, GSK, Roche, Janssen, Novartis, Sunesis, AstraZeneca; Research Funding: Amgen, Abbvie, Celgene, Gilead, GSK, Roche, Janssen, Novartis, Sunesis, AstraZeneca.
