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IMS 2024 | Updates on HBI0101, a CAR T-cell therapy, for R/R multiple myeloma

Eyal Lebel, MD, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, discussed advancements in anti-BCMA CAR T-cell therapy for relapsed/refractory (R/R) multiple myeloma (MM), emphasizing its efficacy and the challenges of high cost, limited availability, and lengthy waiting periods. Dr Lebel has worked with his team to develop a novel anti-BCMA CAR-T therapy, HBI0101 (NXC-201), and here he presents some safety and efficacy data from a Phase I clinical trial testing this product. Despite a high proportion of the study population being frail, a 92% response rate was observed. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.

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