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IWWM-11 2022 | Promising novel treatment approaches in WM: non-covalent BTKis and immunotherapies

Jorge Castillo, MD, Dana-Farber Cancer Institute, Boston, MA, discusses promising novel treatment approaches for patients with Waldenström’s macroglobulinemia (WM), including combination approaches with Bruton’s tyrosine kinase (BTK) inhibitors, and non-covalent BTK inhibitors, such as pirtobrutinib and nemtabrutinib. Dr Castillo also highlights the promise of several immunotherapies, including antibody-drug conjugates (ADCs), bispecific T-cell engagers (BiTEs), and CAR-T cell therapy. This interview took place at the 11th International Workshop on Waldenström’s Macroglobulinemia (IWWM-11), held in Madrid, Spain.

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Consulting fees or research funds from Abbvie, AstraZeneca, BeiGene, Casma, Cellectar, Janssen, Pharmcyclics, Roche, TG Therapeutics.

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