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ASH 2022 | The effect of splicing factor gene mutations on the outcomes of patients with AML

Jayastu Senapati, MBBS, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the results of a retrospective study evaluating the impact of splicing factor gene mutations on the outcomes of patients with acute myeloid leukemia (AML). Patients with newly diagnosed AML were stratified based on splicing factor gene mutational status, age, therapy intensity and whether they received venetoclax or not. Splicing gene mutations in isolation did not affect overall survival (OS) or response. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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